S-Adenosyl methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from
adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation,
transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions
occur throughout the body, most SAM is produced and consumed in the liver.

1. Ademetionine Disulfate Tosylate is a good nutrition for the liver,can prevent alcohol, drugs and the liver-cell injury;

2. Ademetionine Disulfate Tosylate has remarkable preventive effects on chronic active hepatitis, and other factors caused liver injury,heart   disease, cancer and so on.

3. Ademetionine Disulfate Tosylate has been found to be as effective as pharmaceutical treatments for arthritis and major depression as well.   

4. In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled Ademetionine Disulfate Tosylate or Ademetionine Disulfate Tosylate). Some research has indicated that taking SAM on a regular basis help fight depression, liver disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions and osteoarthritis. All other indications are not yet proven.