Basic Information

L-5-Methyltetrahydrofolate Calcium(Levomefolate calcium), a naturally occurring form of halogenated methyl derivatives of folic acid, is the most biologically active and functional form of folic acid and is more easily absorbed than normal folic acid.Lack of folic acid is usually caused by a lack of vitamin deficiency leads to absorb, during pregnancy and lactation, children need more folic acid during the period of growth, the absorption or metabolic changes, or under the influence of drugs, to eat food rich in folic acid can't guarantee dose, so need to supplement.

About 10 years ago, Europe has use L-5-Methyltetrahydrofolate Calcium in drug, 
it has affecting the treatment of pregnant care, homocysteine control, depression, 
ementia and cardiovascular disease.

1. Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
2. Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.
3. as adjuvant therapy for colon cancer, rectal cancer.
4. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
5. For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued.